HIV: implication in Burkitt lymphoma.

Burkitt lymphoma in adults.

This review will begin with a detail of the revision of the WHO classification, and pathological definitions of Burkitt lymphoma. Over the past several years, molecular understanding of Burkitt lymphoma has improved significantly. Using gene expression profiling, a genomic "signature" of Burkitt lymphoma may be identified, that has fidelity beyond c-myc expression, and the presence of the class...

Sporadic Burkitt Lymphoma: A Case Report

Introduction: Burkitt lymphoma is an aggressive subtype of Hodgkin lymphoma with a doubling time of 25 hours. It is characterized by a MYC gene coding alteration which results from a translocation of chromosome 8 on the MYC gene locus and immunoglobulin heavy-chain locus (IGH) on chromosome 14. Even though HIV infection is associated to an increased risk of Burkitt lymphoma, th...

Burkitt Lymphoma in Uganda

Burkitt Lymphoma in the Mouse

Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Ig kappa) or lambda (Ig lambda) L chain genes and effecting deregulated expression of MYC are the hallmarks of human Burkitt lymphoma (BL). Here we report that lymphomas with striking similarities to BL develop in mice bearing a mutated human MYC gene controlled by a r...

Diagnosis of Burkitt Lymphoma

Clinical presentation in extranodal and nodal sites of rapidly expanding masses in high-risk populations suggests Burkitt lymphoma (BL). Most patients present with advanced disease because of the rapid rate of tumor growth. BL cells have a remarkably short doubling time. Children in equatorial Africa and Papua New Guinea have endemic BL and present with facial tumors in the jaw or orbit, abdomi...